EIF4EBP2 Antibody (OAAB20816)

Catalog No: OAAB20816

Size:100ul

Western blot detection of 4E-BP2 in CHO-K1 cell lysate（A）and CHO-K1 transfected by EGFP-4E-BP2 （B）cell lysate using 4E-BP2 mouse mAb (OAAB20816) (1:1,000 diluted).

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Host: Mouse
• Application: WB
• Additional Information: Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Preservative: 0.03% Proclin300 and 50% glycerol
• Formulation: Purified mouse monoclonal antibody in PBS (pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
• Application Info: WB: 1:1000
• Reference: Pause A.,et al.Nature 371:762-767(1994).
  Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
  Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
  Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
  Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
  

Target Info

• Gene Symbol: EIF4EBP2
• Gene Full Name: eukaryotic translation initiation factor 4E binding protein 2
• Alias Symbols: 4EBP2, PHASII
• NCBI Gene Id: 1979
• Description of Target: This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.
• Uniprot ID: Q13542
• Protein Accession #: NP_004087.1
• Nucleotide Accession #: NM_004096.4
• Molecular Weight: 13 kDa