EIF4EBP1 Antibody (Phospho-Thr37) (OASG00061)

Catalog No: OASG00061

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human 4E-BP1 around the phosphorylation site of T37. Location: 10-90aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr37
• Specificity: Phospho-4E-BP1 (T37) Polyclonal Antibody detects endogenous levels of 4E-BP1 protein only when phosphorylated at T37.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: EIF4EBP1
• Gene Full Name: eukaryotic translation initiation factor 4E binding protein 1
• Alias Symbols: BP-1, 4EBP1, 4E-BP1, PHAS-I
• NCBI Gene Id: 1978; 13685; 116636
• Description of Target: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
• Uniprot ID: Q13541, Q60876, Q62622
• Molecular Weight: 12/35 kDa