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Catalog No: OABF01173
Size:100UL
Price: $409.00
SKU
OABF01173
Availability: 3 to 5 business days.
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)
Product Info
Predicted Species ReactivityBovine|Dog|Horse|Human|Mouse|Rat
Product FormatLiquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
::Modification: Phosphorylation (Thr667)
Reconstitution and Storage-20°C
ImmunogenKLH conjugated synthetic phosphopeptide derived from human GCN2 around the phosphorylation site of Thr667
PurificationProtein A Purified
Concentration1 ug/ul
SpecificityThis phosphorylation site is homologous to Thr666 in Mouse and Thr667 in Rat
Application InfoWB: 1:300-1000
IHC-P: 1:200-400
Fluorescent-IHC: 1:50-200
Optimal dilutions should be determined by the end user.
Publications

Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. J Neurochem. 151, 764-776 (2019). 31539452

Description
Gene SymbolEIF2AK4
Gene Full Nameeukaryotic translation initiation factor 2 alpha kinase 4
Alias SymbolseIF-2-alpha kinase GCN2;Eukaryotic translation initiation factor 2-alpha kinase 4;GCN2;GCN2 eIF2alpha kinase;GCN2-like protein;general control nonderepressible 2;PVOD2.
NCBI Gene Id440275
Protein NameeIF-2-alpha kinase GCN2
Description of TargetMetabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).
Uniprot IDQ9P2K8
  1. What is the species homology for "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Bovine|Dog|Horse|Human|Mouse|Rat".

  2. How long will it take to receive "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    This item is available "3 to 5 business days.".

  3. What buffer format is "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)" provided in?

    This item is provided in "Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    This target may also be called "eIF-2-alpha kinase GCN2;Eukaryotic translation initiation factor 2-alpha kinase 4;GCN2;GCN2 eIF2alpha kinase;GCN2-like protein;general control nonderepressible 2;PVOD2." in publications.

  5. What is the shipping cost for "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "EIF2AK4 Antibody (Phospho-Thr667) (OABF01173)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "EIF2AK4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "EIF2AK4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "EIF2AK4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "EIF2AK4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "EIF2AK4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "EIF2AK4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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