EIF2AK2 Antibody (Phospho-Thr451) (OASG05951)

Catalog No: OASG05951

Size:100 uL

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human PKR around the phosphorylation site of T451. Location: 390-470aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr451
• Specificity: Phospho-PKR (T451) Polyclonal Antibody detects endogenous levels of PKR protein only when phosphorylated at T451.
• Application Info: IHC 1:100-1:300; ELISA 1:20000;

Target Info

• Gene Symbol: EIF2AK2
• Gene Full Name: eukaryotic translation initiation factor 2-alpha kinase 2
• Alias Symbols: PKR, PRKR, LEUDEN, EIF2AK1, PPP1R83
• NCBI Gene Id: 5610;
• Description of Target: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
• Uniprot ID: P19525
• Molecular Weight: 70 kDa