- Tested Species Reactivity:
- Human
- Predicted Species Reactivity:
- Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Clonality:
- Polyclonal
- Host:
- Rabbit
- Application:
- WB
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Gene Symbol:
- EIF2AK2
- Official Gene Full Name:
- Eukaryotic translation initiation factor 2-alpha kinase 2
- NCBI Gene Id:
- 5610
- Protein Name:
- Interferon-induced, double-stranded RNA-activated protein kinase
- Swissprot Id:
- P19525
- Protein Accession #:
- NP_002750
- Nucleotide Accession #:
- NM_002759
- Alias Symbols:
- EIF2AK1, MGC126524, PKR, PRKR
- Replacement Item:
- This antibody may replace item sc-100378 from Santa Cruz Biotechnology.
- Description of Target:
- EIF2AK2 might play a role in ER stress-induced apoptosis and in Alzheimer's disease. Alzheimer cases show prominent EIF2AK2 activation in association with neuritic plaques and pyramidal neurons in the hippocampus and neocortex.
- Protein Size (# AA):
- 551
- Molecular Weight:
- 62kDa
- Purification:
- Affinity Purified
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express EIF2AK2.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express EIF2AK2.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human EIF2AK2
- Predicted Homology Based on Immunogen Sequence:
- Cow: 92%; Dog: 83%; Horse: 91%; Human: 100%; Mouse: 83%; Pig: 83%; Rabbit: 100%; Rat: 92%
- Complete computational species homology data:
- Anti-EIF2AK2 (ARP36709_P050)
- Peptide Sequence:
- Synthetic peptide located within the following region: QVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDG
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- UBC; TRAF6; TRAF5; TRAF2; EGFR; DHX9; STAU2; PRKRA; EIF2AK2; HECW2; TOP1; STAU1; DICER1; DHX30; EBNA1BP2; IGF2BP2; IGF2BP3; PABPC4; MOV10; ILF3; ILF2; HSP90AA1; EIF2A; NOC3L; GNL3; NOP2; HNRNPC; HIST1H1C; ELAVL1; NPM1; IL7R; gag; Jak2; TYK2; JAK1; EIF2S1;
- Blocking Peptide:
- For anti-EIF2AK2 (ARP36709_P050) antibody is Catalog # AAP36709 (Previous Catalog # AAPP08602)
- Datasheets/Manuals:
- Printable datasheet for anti-EIF2AK2 (ARP36709_P050) antibody
- Sample Type Confirmation:
EIF2AK2 is strongly supported by BioGPS gene expression data to be expressed in HeLa
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