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Catalog No: OACA06859
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OACA06859
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for EGLN1 Antibody (OACA06859) (OACA06859)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunohistochemistry
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Egl nine homolog 1 protein (301-426AA)
PurificationAffinity Purified
Preservative0.02% sodium azide
FormulationPBS with, 50% glycerol, pH7.3.
Reference[1]"A genetic mechanism for Tibetan high-altitude adaptation." Lorenzo F.R., Huff C., Myllymaeki M., Olenchock B., Swierczek S., Tashi T., Gordeuk V., Wuren T., Ri-Li G., McClain D.A., Khan T.M., Koul P.A., Guchhait P., Salama M.E., Xing J., Semenza G.L., Liberzon E., Wilson A. Prchal J.T.Nat. Genet. 46:951-956(2014). [2]"Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing."Song D., Li L.S., Arsenault P.R., Tan Q., Bigham A.W., Heaton-Johnson K.J., Master S.R., Lee F.S.J. Biol. Chem. 289:14656-14665(2014). [3]"A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove."Percy M.J., Furlow P.W., Beer P.A., Lappin T.R.J., McMullin M.F., Lee F.S.Blood 110:2193-2196(2007).
Gene SymbolEGLN1
Gene Full Nameegl-9 family hypoxia inducible factor 1
Alias SymbolsC1orf12;ECYT3;egl nine homolog 1;egl nine-like protein 1;HALAH;HIFPH2;HIF-PH2;HIF-prolyl hydroxylase 2;HPH2;HPH-2;hypoxia-inducible factor prolyl hydroxylase 2;PHD2;prolyl hydroxylase domain-containing protein 2;SM20;SM-20;zinc finger MYND domain-containing protein 6;ZMYND6.
NCBI Gene Id54583
Protein NameEgl nine homolog 1
Description of TargetCellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
Uniprot IDQ9GZT9
Protein Accession #NP_071334
Nucleotide Accession #NM_022051
  1. What is the species homology for "EGLN1 Antibody (OACA06859)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "EGLN1 Antibody (OACA06859)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "EGLN1 Antibody (OACA06859)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "EGLN1 Antibody (OACA06859)"?

    This target may also be called "C1orf12;ECYT3;egl nine homolog 1;egl nine-like protein 1;HALAH;HIFPH2;HIF-PH2;HIF-prolyl hydroxylase 2;HPH2;HPH-2;hypoxia-inducible factor prolyl hydroxylase 2;PHD2;prolyl hydroxylase domain-containing protein 2;SM20;SM-20;zinc finger MYND domain-containing protein 6;ZMYND6." in publications.

  5. What is the shipping cost for "EGLN1 Antibody (OACA06859)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "EGLN1 Antibody (OACA06859)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "EGLN1 Antibody (OACA06859)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "EGLN1 Antibody (OACA06859)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "EGLN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "EGLN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "EGLN1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "EGLN1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "EGLN1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "EGLN1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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