Catalog No: OPCA01231
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EFNA1 Recombinant Protein (Rat) (OPCA01231)

Datasheets/ManualsPrintable datasheet for EFNA1 Recombinant Protein (Rat) (OPCA01231) (OPCA01231)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatLiquid or Lyophilized powder
Additional Information Tag information : His tag
Reconstitution and Storage-20°C or -80°C
PurityGreater than 90% as determined by SDS-PAGE.
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Protein Range18-182 aa
TagN-terminal 6xHis-tagged
ReferenceMolecular cloning and expression of rat and mouse B61 gene implications on organogenesis.Takahashi H., Ikeda T.Oncogene 11:879-883(1995)
Gene SymbolEfna1
Gene Full Nameephrin A1
Alias SymbolsB61;EPH-related receptor tyrosine kinase ligand 1;ephrin-A1;immediate early response protein B61;LERK-1.
NCBI Gene Id94268
Protein NameEphrin-A1
Description of TargetCell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity).
Uniprot IDP97553
Protein Size (# AA)Recombinant
Molecular Weight21.4 kDa
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