EFHD2 Antibody (OAPB01065)

Catalog No: OAPB01065

Size:100UG

Immunohistochemistry of EFHD2 in human brain tissue with EFHD2 antibody at 5 μg/mL.

Immunofluorescence of EFHD2 in human brain tissue with EFHD2 antibody at 20 μg/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. EFHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: EFHD2 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: EFHD2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human EFHD2. The immunogen is located within the first 50 amino acids of EFHD2.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-EFHD2 antibody is Catalog # OEPB03182
• Application Info: EFHD2 antibody can be used for detection of EFHD2 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
• Reference: Kroczek C, Lang C, Brachs S, et al. Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts. J. Immunol.2010; 184:3665-76.;Avramidou A, Kroczek C, Lang C, et al. The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Cell Death Differ.2007; 14:1936-47.;Thylur RP, Kiim YD, Kwon MS, et al. Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. J. Cell Biochem.2009; 108:705-15.;

Target Info

• Gene Symbol: EFHD2
• Gene Full Name: EF-hand domain family member D2
• Alias Symbols: EF hand domain containing 2;EF-hand domain-containing protein D2;swiprosin 1;Swiprosin-1;SWS1;testicular tissue protein Li 62.
• NCBI Gene Id: 79180
• Protein Name: EF-hand domain-containing protein D2|EF-hand domain-containing protein D2 [Homo sapiens]
• Description of Target: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
• Uniprot ID: Q96C19
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_077305