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EDN3 Antibody (OAGA01038)

100 ul
$409.00
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB
Additional Information:
Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq]
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Positive Controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
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Cellular Localization: Secreted
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Gene Symbol:
EDN3
Official Gene Full Name:
Endothelin-3
NCBI Gene Id:
1908
Protein Name:
Endothelin-3
Swissprot Id:
P14138
Protein Accession #:
NP_000105.1
Alias Symbols:
ET3 antibody, HSCR4 antibody, MGC15067 antibody, MGC61498 antibody, WS4B antibody, EDN3 antibody, endothelin-3 antibody, preproendothelin-3 antibody, endothelin 3 antibody
Molecular Weight:
25 kDa
Purification:
Purified by antigen-affinity chromatography.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express EDN3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express EDN3.
Immunogen:
Recombinant fragment corresponding to a region within amino acids 1 and 217 of ET-3 (Uniprot ID#P14138)
Concentration:
0.52 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-EDN3 antibody - OAGA01038
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Storage Buffer:
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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