ECD Antibody - middle region (ARP88461_P050)

Catalog No: ARP88461_P050

Host: Rabbit
Target Name: ECD
Sample Tissue: Human HepG2 Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ECD
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: PSEAPITFDADSFLNYFDKILGPRPNESDSDDLDDEDFECLDSDDDLDFE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ECD (ARP88461_P050) antibody is Catalog # AAP88461

Target Info

• Gene Symbol: ECD
• Gene Full Name: ecdysoneless cell cycle regulator
• Alias Symbols: GCR2, SGT1, HSGT1
• NCBI Gene Id: 11319
• Protein Name: Protein ecdysoneless homolog
• Description of Target: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
• Uniprot ID: O95905
• Protein Accession #: NP_001129224.1
• Nucleotide Accession #: NM_001135752.1
• Protein Size (# AA): 644
• Molecular Weight: 70 kDa