E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947)

Catalog No: OPCA02947

E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) in SDS-PAGE showing the molecular weight of approximately 14 kDa.

E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) in SDS-PAGE showing the molecular weight of approximately 14 kDa.

Product Info

• Predicted Species Reactivity: Human papillomavirus type 18|Human Papillomavirus Type 18
• Product Format: Liquid or Lyophilized powder
• Host: Human
• Additional Information: Protein Description: Full length
  Subcellular Location: Host cytoplasm, Host nucleus
• Reconstitution and Storage: -20°C or -80°C
• Purification: Affinity purified using IMAC
• Concentration: Varies by lot. See vial for exact concentration.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Peptide Sequence: MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
• Protein Sequence: MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
• Storage Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Source: Yeast
• Protein Range: 1-105 aa
• Tag: N-terminal 6xHis-tagged
• Reference: Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987)

Target Info

• Gene Symbol: E7
• Alias Symbols: E7Protein E7
• Protein Name: Protein E7
• Description of Target: Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230).
• Uniprot ID: P06788
• Protein Size (# AA): Recombinant
• Molecular Weight: 14 kDa