Catalog No: OPCA02947
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Product Info
Predicted Species ReactivityHuman papillomavirus type 18|Human Papillomavirus Type 18
Product FormatLiquid or Lyophilized powder
Additional InformationProtein Description: Full length
Subcellular Location: Host cytoplasm, Host nucleus
Reconstitution and Storage-20°C or -80°C
PurificationAffinity purified using IMAC
ConcentrationVaries by lot. See vial for exact concentration.
PurityGreater than 90% as determined by SDS-PAGE.
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Protein Range1-105 aa
TagN-terminal 6xHis-tagged
ReferenceNucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987)
Gene SymbolE7
Alias SymbolsE7Protein E7
Protein NameProtein E7
Description of TargetPlays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230).
Uniprot IDP06788
Protein Size (# AA)Recombinant
Molecular Weight14 kDa
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