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E2F1 Antibody (OABF00215)

100 ul
$359.00
In Stock
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Conjugation Options

OABF00215-FITC Conjugated

OABF00215-HRP Conjugated

OABF00215-Biotin Conjugated

Gene Symbol:
E2F1
Official Gene Full Name:
E2F transcription factor 1
NCBI Gene Id:
1869
Swissprot Id:
Q01094
Alias Symbols:
RBP3, E2F-1, RBAP1, RBBP3,
Replacement Item:
This antibody may replace item sc-116659 from Santa Cruz Biotechnology.
Description of Target:
E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by Protein A.
Application:
WB, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express E2F1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express E2F1.
Immunogen:
KLH conjugated synthetic peptide derived from human E2F1
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Reconstitution and Storage:
Store at -20C for 12 months.
Concentration:
1ug/ul
Datasheets/Manuals:
Printable datasheet for OABF00215
Conjugation:
Unconjugated
Isotype:
IgG
Application Info:
WB: 1:100 - 1000
IHC-P: : 1:100 - 500
Additional Information:
Subcellular location: Nucleus

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