DYRK2 Antibody - N-terminal region (OAAB17096)

Catalog No: OAAB17096

Size:400ul

The anti-DYRK2 Pab (Cat. # OAAB17096) is used in Western blot to detect DYRK2 in 293 cell lysate.

DYRK2 is strongly supported by BioGPS gene expression data to be expressed in HEK293

DYRK2 Antibody (N-term) (Cat. # OAAB17096) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DYRK2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Precautions: DYRK2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro)
  Cellular Location: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage
  Tissue Location: Testis, after the onset of spermatogenesis.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This DYRK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-135 amino acids from the N-terminal region of human DYRK2.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  DYRK2 is strongly supported by BioGPS gene expression data to be expressed in HEK293

• Application Info: WB: 1:8000
  WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: DYRK2
• Alias Symbols: DYRK2, Dual specificity tyrosine-phosphorylation-regulated kinase 2
• NCBI Gene Id: 8445
• Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 2
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q92630
• Protein Accession #: NP_003574.1
• Molecular Weight: 66652 Da