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Catalog No: ARP45797_P050
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ARP45797_P050
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Datasheets/ManualsPrintable datasheet for anti-DYRK1A (ARP45797_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human DYRK1A
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Peptide SequenceSynthetic peptide located within the following region: INEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWM
Concentration0.5 mg/ml
Blocking PeptideFor anti-DYRK1A (ARP45797_P050) antibody is Catalog # AAP45797 (Previous Catalog # AAPP26741)
Gene SymbolDYRK1A
Gene Full NameDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Alias SymbolsMNB, DYRK, HP86, MNBH, MRD7, DYRK1
NCBI Gene Id1859
Protein NameDual specificity tyrosine-phosphorylation-regulated kinase 1A
Description of TargetThis gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Uniprot IDQ13627
Protein Accession #NP_001387
Nucleotide Accession #NM_001396
Protein Size (# AA)763
Molecular Weight85kDa
Protein InteractionsSUMO1; UBC; CCDC8; FAM117A; FAM53C; SIPA1L1; DCAF7; TROAP; KIAA0232; DYNLL1; RBL2; RBL1; RB1; ABCD3; PRKAR1A; FNTB; FNTA; EP300; DYRK1A; CREBBP; CCNA2; RNF169; FAM117B; DYNLL2; GLCCI1; PPP1R3F; LZTS2; PRKACB; PRKACA; TRAF3; BARD1; SNCA; MAP3K5; APP; SMAD3
  1. What is the species homology for "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".

  2. How long will it take to receive "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "DYRK1A Antibody - N-terminal region (ARP45797_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    This target may also be called "MNB, DYRK, HP86, MNBH, MRD7, DYRK1" in publications.

  5. What is the shipping cost for "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "85kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "DYRK1A Antibody - N-terminal region (ARP45797_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "DYRK1A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DYRK1A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DYRK1A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DYRK1A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DYRK1A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DYRK1A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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