DYNLL1 Antibody - N-terminal region (ARP51350_P050)

Catalog No: ARP51350_P050

WB Suggested Anti-DYNLL1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Transfected 293T

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYNLL1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKY
• Concentration: 0.5 mg/ml
• Blocking Peptide: Catalog # AAP51350 (Previous Catalog # AAPP28705)
• Reference: Song,C., (2008) J. Biol. Chem. 283 (7), 4004-4013

Target Info

• Gene Symbol: DYNLL1
• Gene Full Name: Dynein, light chain, LC8-type 1
• Alias Symbols: LC8, PIN, DLC1, DLC8, LC8a, DNCL1, hdlc1, DNCLC1
• NCBI Gene Id: 8655
• Protein Name: Dynein light chain 1, cytoplasmic
• Description of Target: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
• Uniprot ID: P63167
• Protein Accession #: NP_001032583
• Nucleotide Accession #: NM_001037494
• Protein Size (# AA): 89
• Molecular Weight: 10kDa
• Protein Interactions: UBC; DYNC1I1; CCDC36; IQUB; AMBRA1; AMOTL2; KANK2; BECN1; BMI1; EED; GNB2L1; RPS21; RPS5; RPS3; RPS2; RPSA; HDLBP; FKBP3; FAU; DYNC1LI2; NRF1; AMOT; DYRK1B; DYRK1A; TERT; STK24; PRKACB; PRKACA; GSK3B; STK26; STK25; CSNK1A1; PAK1; UL122; IQCB1; BCL2L11; NA