DUSP6 Recombinant Protein (Human) (OPED00087)

Catalog No: OPED00087

Size:100UG

SDS-PAGE Analysis. Lane 1: MW Marker, Lane 2: 1 ug, Lane 3: 2 ug, Lane 4: 5 ug MKP-3.

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid. In 20mM TRIS/HCl, pH 8.0, 200mM NaCl, 5mM DTT, 0.1 % Tween-20, 10% glycerol.
• Host: Sf9 cells
• Additional Information: MKP-3 is a member of a group of dual specificity phosphatases which negatively regulate MAP kinases, dephosphorylating both the phosphotyrosine and phosphothreonine in the pTXpY activation loop motif. Transcriptional suppression of MKP-3 expression has been implicated in the development of pancreatic cancer. MKP-3 is located in the nucleus where it may act to anchor Erk 1/2.
• Reconstitution and Storage: Store at -80C
• Purification: Partially purified by single-step affinity chromatography and gel filtration.

Target Info

• Gene Symbol: DUSP6
• Gene Full Name: dual specificity phosphatase 6
• Alias Symbols: dual specificity protein phosphatase 6;dual specificity protein phosphatase PYST1;HH19;MAP kinase phosphatase 3;mitogen-activated protein kinase phosphatase 3;MKP3;PYST1;serine/threonine specific protein phosphatase.
• NCBI Gene Id: 1848
• Protein Name: Dual specificity protein phosphatase 6
• Description of Target: Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).
• Uniprot ID: Q16828
• Protein Accession #: NP_004647.1
• Nucleotide Accession #: NM_004656.3
• Protein Size (# AA): Recombinant
• Molecular Weight: 42 kDa