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Catalog No: OASG04554
Size:100 uL
Price: $239.00
SKU
OASG04554
Availability: Domestic: within 2-3 weeks delivery | International: 2-3 weeks
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DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)

Datasheets/ManualsPrintable datasheet for anti-DUSP1 (OASG04554) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLiquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationWB, IHC
Reconstitution and StorageStore at -20C. Avoid repeated freeze/thaw cycles.
ImmunogenSynthesized peptide derived from human MKP-1/2 around the phosphorylation site of S296/318. Location: 230-310aa.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration1 mg/ml
Target Post-Translational ModificationPhospho-Ser296/318
SpecificityPhospho-MKP-1/2 (S296/318) Polyclonal Antibody detects endogenous levels of MKP-1/2 protein only when phosphorylated at S296/318.
Application InfoWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Gene SymbolDUSP1, DUSP4
Gene Full Namedual specificity phosphatase 1
Alias SymbolsHVH1, MKP1, CL100, MKP-1, PTPN10
NCBI Gene Id1843; 1846; 19252; 319520; 114856; 60587
Description of TargetThe expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Uniprot IDP28562, Q13115, P28563, Q8BFV3, Q64623, Q62767
Molecular Weight45 kDa
  1. What is the species homology for "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    This item is available "Domestic: within 2-3 weeks delivery | International: 2-3 weeks".

  3. What buffer format is "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)" provided in?

    This item is provided in "Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    This target may also be called "HVH1, MKP1, CL100, MKP-1, PTPN10" in publications.

  5. What is the shipping cost for "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "45 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "DUSP1 Antibody (Phospho-Ser296/318) (OASG04554)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "DUSP1, DUSP4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DUSP1, DUSP4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DUSP1, DUSP4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DUSP1, DUSP4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DUSP1, DUSP4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DUSP1, DUSP4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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