DTNBP1 Recombinant Protein (OPCD00124)

Catalog No: OPCD00124

DTNBP1 Recombinant Protein (OPCD00124) using SDS-PAGE

DTNBP1 Recombinant Protein (OPCD00124) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Rat|Rattus norvegicus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Asp110-Leu305
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Dtnbp1
• Gene Full Name: dystrobrevin binding protein 1
• Alias Symbols: biogenesis of lysosome-related organelles complex 1 subunit 8;BLOC-1 subunit 8;distrobrevin binding protein 1;dysbindin;dysbindin-1;Dystrobrevin-binding protein 1.
• NCBI Gene Id: 641528
• Protein Name: Dysbindin
• Description of Target: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
• Uniprot ID: Q5M834
• Protein Accession #: NP_001032753.1
• Nucleotide Accession #: NM_001037664.1
• Protein Size (# AA): Asp110~Leu305
• Molecular Weight: 28kDa