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Catalog No: OACA10257
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OACA10257
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for DTL Antibody (OACA10257) (OACA10257)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunohistochemistry
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Denticleless protein homolog protein (393-550AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, PH 7.4
Purity>95%
Gene SymbolDTL
Gene Full Namedenticleless E3 ubiquitin protein ligase homolog
Alias SymbolsCDT2;DCAF2;DDB1- and CUL4-associated factor 2;denticleless protein homolog;L2DTL;lethal(2) denticleless protein homolog;RAMP;RA-regulated nuclear matrix-associated protein;retinoic acid-regulated nuclear matrix-associated protein.
NCBI Gene Id51514
Protein NameDenticleless protein homolog
Description of TargetSubstrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613).
Uniprot IDQ9NZJ0
Protein Accession #NP_001273158
Nucleotide Accession #NM_001286229
  1. What is the species homology for "DTL Antibody (OACA10257)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "DTL Antibody (OACA10257)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "DTL Antibody (OACA10257)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "DTL Antibody (OACA10257)"?

    This target may also be called "CDT2;DCAF2;DDB1- and CUL4-associated factor 2;denticleless protein homolog;L2DTL;lethal(2) denticleless protein homolog;RAMP;RA-regulated nuclear matrix-associated protein;retinoic acid-regulated nuclear matrix-associated protein." in publications.

  5. What is the shipping cost for "DTL Antibody (OACA10257)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "DTL Antibody (OACA10257)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "DTL Antibody (OACA10257)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "DTL Antibody (OACA10257)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "DTL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DTL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DTL"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DTL"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DTL"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DTL"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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