Size:400ul
$329.00
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OAAB00993
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DTL Antibody - middle region (OAAB00993)

Catalog#: OAAB00993
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species Reactivity Human, Mouse
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality Polyclonal
Isotype Rabbit Ig
Host Rabbit
Application WB, FC
:: Cellular Location: Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Tissue Location: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen This DTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-256 amino acids from the Central region of human DTL.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for anti-DTL antibody - OAAB00993
Intended Use For research use only.
Application Info WB: 1:1000
FC: 1:10~50
Publications

Tateossian, H; Morse, S; Simon, MM; Dean, CH; Brown, SD; Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. 8, 1531-42 (2015). WB, FC, Human, Mouse 26471094

Gene Symbol DTL
Alias Symbols Denticleless protein homolog, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP
NCBI Gene Id 51514
Protein Name Denticleless protein homolog
Description of Target Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Swissprot Id Q9NZJ0
Protein Accession # NP_057532.2
Molecular Weight 79468 Da
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express DTL.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express DTL.
  1. What is the species homology for "DTL Antibody - middle region (OAAB00993)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "DTL Antibody - middle region (OAAB00993)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "DTL Antibody - middle region (OAAB00993)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide. ".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "DTL Antibody - middle region (OAAB00993)"?

    This target may also be called "Denticleless protein homolog, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP" in publications.

  5. What is the shipping cost for "DTL Antibody - middle region (OAAB00993)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "DTL Antibody - middle region (OAAB00993)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "DTL Antibody - middle region (OAAB00993)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "79468 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "DTL Antibody - middle region (OAAB00993)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "DTL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DTL"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DTL"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DTL"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DTL"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DTL"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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