In Stock
Request Bulk
Order Quote
Contact Us:
  • Toll Free: (888)880-0001
  • Phone: (858)552-6979
  • Email:
Shipping Info:
  • $40: Antibody & Protein in US
  • $50: 1-2 Kits in US
  • Contact us for international orders.

DTL Antibody - middle region (OAAB00993)

Catalog#: OAAB00993
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
IsotypeRabbit Ig
ApplicationWB, FC
::Cellular Location: Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Tissue Location: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis DTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-256 amino acids from the Central region of human DTL.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/ManualsPrintable datasheet for anti-DTL antibody - OAAB00993
Intended UseFor research use only.
Application InfoWB: 1:1000
FC: 1:10~50

Tateossian, H; Morse, S; Simon, MM; Dean, CH; Brown, SD; Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. 8, 1531-42 (2015). WB, FC, Human, Mouse 26471094

Gene SymbolDTL
Alias SymbolsDenticleless protein homolog, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP
NCBI Gene Id51514
Protein NameDenticleless protein homolog
Description of TargetSubstrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Swissprot IdQ9NZJ0
Protein Accession #NP_057532.2
Molecular Weight79468 Da
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express DTL.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express DTL.
Write Your Own Review
You're reviewing:DTL Antibody - middle region (OAAB00993)
Your Rating
Aviva HIS tag Deal
Aviva Tissue Tool
Aviva ChIP Antibodies
Free Microscope