DSG2 Antibody (OAGA00185)

Catalog#: OAGA00185

• Size: 100 ul

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: ICC, IF, IHC-FFPE, WB
• Additional Information: Background: Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq]
  Positive Controls: 293T, H1299, Molt-4
  Cellular Localization: Cell membrane, Cell junction, desmosome
• Reconstitution and Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Replacement Item: This antibody may replace item sc-135815 from Santa Cruz Biotechnology.
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 206 of Desmoglein 2 (Uniprot ID#Q14126)
• Purification: Purified by antigen-affinity chromatography.
• Concentration: 1 mg/ml
• Application Info: Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000 [suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)], ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
• Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Gene Symbol: DSG2
• Official Gene Full Name: Desmoglein-2
• Alias Symbols: ARVC10 antibody, ARVD10 antibody, CDHF5 antibody, CMD1BB antibody, HDGC antibody, MGC117034 antibody, MGC117036 antibody, MGC117037 antibody, DSG2 antibody, cadherin family member 5 antibody, desmoglein-2 antibody, desmoglein 2 antibody
• NCBI Gene Id: 1829
• Protein Name: Desmoglein-2
• Swissprot Id: Q14126
• Protein Accession #: NP_001934.2
• Molecular Weight: 122 kDa
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express DSG2.

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