DPYSL2 Antibody (OAAB06635)

Catalog No: OAAB06635

Size:400ul

All lanes : Anti-DRP-2 Antibody at 1:128000 dilution Lane 1: human brain lysate Lane 2: mouse brain lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 62 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Western blot analysis of lysate from mouse NIH/3T3 cell line, using DRP-2 Antibody(33CT11. 7. 6). 33CT11. 7. 6 was diluted at 1:2000. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 20ug.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Clonality: Monoclonal
• Clone: 33CT11.40.3
• Isotype: IgG2b
• Host: Mouse
• Application: WB
• Additional Information: Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
  Cellular Location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes
  Tissue Location: Ubiquitous.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This DRP-2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from human DRP-2.
• Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
• Predicted Homology Based on Immunogen Sequence: Cow; Human; Mouse; Rat; Chicken
• Application Info: WB: 1:8000
  WB: 1:128000
• Intended Use: DRP-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Target Info

• Gene Symbol: DPYSL2
• Alias Symbols: DRP2, N2A3, CRMP2, DRP-2, ULIP2, CRMP-2, DHPRP2, ULIP-2
• NCBI Gene Id: 1808
• Protein Name: Dihydropyrimidinase-related protein 2
• Description of Target: A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. Koide T, et al. J Hum Genet, 2010 Jul. PMID 20414250. Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 Apr 8. PMID 20381070. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Chae YC, et al. Cell Signal, 2009 Dec. PMID 19666111. CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. Arimura N, et al. J Neurochem, 2009 Oct. PMID 19659462.
• Uniprot ID: Q16555, P47942, O08553, Q90635, O02675
• Protein Accession #: NP_001184222.1
• Molecular Weight: 62294 Da