- Gene Symbol:
- DR1
- NCBI Gene Id:
- 1810
- Official Gene Full Name:
- Down-regulator of transcription 1, TBP-binding (negative cofactor 2)
- Protein Name:
- Protein Dr1
- Swissprot Id:
- Q01658
- Protein Accession #:
- NP_001929
- Nucleotide Accession #:
- NM_001938
- Alias Symbols:
- NC2, NC2-BETA
- Replacement Item:
- This antibody may replace item sc-133522 from Santa Cruz Biotechnology.
- Description of Target:
- DR1 is a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. DR1 is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. DR1 contains a histone fold motif
- Protein Size (# AA):
- 176
- Molecular Weight:
- 19kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Protein A purified
- Application:
- WB
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express DR1.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express DR1.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human DR1
- Tested Species Reactivity:
- Human
- Predicted Homology Based on Immunogen Sequence:
- Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
- Complete computational species homology data:
- Anti-DR1 (ARP38085_T100)
- Peptide Sequence:
- Synthetic peptide located within the following region: MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLI
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- POLE3; TBP; UBC; BTF3L4; LRSAM1; GOPC; NPLOC4; IPO11; DBNL; ARIH1; TTLL12; ARPC1B; UBE3A; METTL1; HSF1; XPO1; YEATS2; DRAP1; CREB1; CCDC101; TADA2B; SUPT20H; MBIP; WDR5; TADA3; KAT2B; MAP3K7; TADA2A; KAT2A; DR1; ELAVL1; NFYC; NFIL3; TTF2; IRF1;
- Blocking Peptide:
- For anti-DR1 (ARP38085_T100) antibody is Catalog # AAP38085 (Previous Catalog # AAPP20259)
- Datasheets/Manuals:
- Printable datasheet for anti-DR1 (ARP38085_T100) antibody
- Target Reference:
- Gilfillan,S., et al., (2005) J. Biol. Chem. 280 (7), 6222-6230
- Publications:
Deng, W., Malecová, B., Oelgeschläger, T. & Roberts, S. G. E. TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation. Mol. Cell. Biol. 29, 1389-400 (2009). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 19114554
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