DPP4 Antibody (OAEE00164)

Catalog No: OAEE00164

Size:100UG

Surface staining of human peripheral blood cells with anti-human CD26 (BA5b) purified, GAM-APC.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: BA5b
• Isotype: IgG2a
• Host: Mouse
• Application: Flow cytometry
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: A human T cell clone
• Purification: Purified
• Concentration: 1 mg/ml
• Specificity: The mouse monoclonal antibody BA5b recognizes CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.
  HLDA VI; WS Code N-L078
  
• Formulation: Purified
• Purity: > 95% (by SDS-PAGE)
• Storage Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Reference: Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
  Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
  Wong PT, Wong CK, Tam LS, Li EK, Chen DP, Lam CW: Decreased expression of T lymphocyte co-stimulatory molecule CD26 on invariantnatural killer T cells in systemic lupus erythematosus. Immunol Invest. 2009;38(5):350-64.
  Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein anddipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology. 2009 Oct;55(4):432-40.
  Kotacková L, Baláziová E, Sedo A: Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer. Folia Biol (Praha). 2009;55(3):77-84.
  Stremenova J, Krepela E, Mares V, Trim J, Dbaly V, Marek J, Vanickova Z, Lisa V, Yea C, Sedo A: Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade. Int J Oncol. 2007 Oct;31(4):785-92.
  Ellingsen T, Hornung N, Møller BK, Hjelm-Poulsen J, Stengaard-Pedersen K: In active chronic rheumatoid arthritis, dipeptidyl peptidase IV density is increased on monocytes and CD4(+) T lymphocytes. Scand J Immunol. 2007 Oct;66(4):451-7.

Target Info

• Gene Symbol: DPP4
• Gene Full Name: dipeptidyl peptidase 4
• Alias Symbols: ADABP;ADCP2;ADCP-2;adenosine deaminase complexing protein 2;CD26;dipeptidyl peptidase 4;dipeptidyl peptidase IV;dipeptidylpeptidase 4;dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);DPP IV;DPPIV;Gly-Pro naphthylamidase;Post-proline dipeptidyl aminopeptidase IV;T-cell activation antigen CD26;TP103;Xaa-Pro-dipeptidylaminopeptidase.
• NCBI Gene Id: 1803
• Protein Name: Dipeptidyl peptidase 4
• Description of Target: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
• Uniprot ID: P27487
• Protein Accession #: NP_001926.2
• Nucleotide Accession #: NM_001935.3