DPH1 Antibody (OACA06116)

Catalog No: OACA06116

Immunohistochemistry of paraffin-embedded human ovarian cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human ovarian cancer at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 protein (192-318AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Reference: [1]"Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor."Salicioni A.M., Xi M., Vanderveer L.A., Balsara B., Testa J.R., Dunbrack R.L. Jr., Godwin A.K.Genomics 69:54-62(2000). [2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004).

Target Info

• Gene Symbol: DPH1
• Gene Full Name: diphthamide biosynthesis 1
• Alias Symbols: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1;candidate tumor suppressor in ovarian cancer 1;DEDSSH;diphthamide biosynthesis protein 1;diphthamide biosynthesis protein 2 homolog-like 1;diphtheria toxin resistance protein 1;diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1;DPH1 homolog;DPH2L;DPH2L1;DPH2-like 1;DPH-like 1;ovarian cancer-associated gene 1 protein;ovarian tumor suppressor candidate 1;OVCA1;S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1.
• NCBI Gene Id: 1801
• Protein Name: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
• Description of Target: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).
• Uniprot ID: Q9BZG8
• Protein Accession #: NP_001374
• Nucleotide Accession #: NM_001383