DPF3 Antibody - C-terminal (OAPB01822)

Catalog No: OAPB01822

Size:100UG

Western blot analysis of DPF3 in mouse brain tissue lysate with DPF3 antibody at (A) 1 and (B) 2 ug/ml.

Product Info

• Predicted Species Reactivity: Chicken|Human|Mouse
• Product Format: Liquid. DPF3 antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: DPF3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DPF3. The immunogen is located within amino acids 220 - 270 of DPF3.
• Purification: Affinity Purified
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: DPF3
• Gene Full Name: double PHD fingers 3
• Alias Symbols: BAF45C;BRG1-associated factor 45C;CERD4;D4, zinc and double PHD fingers, family 3;SMARCG3;zinc finger protein cer-d4;zinc finger protein DPF3.
• NCBI Gene Id: 8110
• Protein Name: Zinc finger protein DPF3|zinc finger protein DPF3 isoform 1 [Homo sapiens]
• Description of Target: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.
• Uniprot ID: Q92784
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_036206
• Nucleotide Accession #: NM_001280542.1
• Molecular Weight: Predicted: 39 kDa Observed: 50 kDa