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Catalog No: OACA10713
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OACA10713
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Datasheets/ManualsPrintable datasheet for DNMT3L Antibody (OACA10713) (OACA10713)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Western blot
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human DNA (cytosine-5)-methyltransferase 3-like protein (1-234AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, pH 7.4
Purity>95%
Gene SymbolDNMT3L
Gene Full NameDNA methyltransferase 3 like
Alias Symbolscytosine-5-methyltransferase 3-like protein;DNA (cytosine-5)-methyltransferase 3-like;DNA (cytosine-5-)-methyltransferase 3-like;human cytosine-5-methyltransferase 3-like protein.
NCBI Gene Id29947
Protein NameDNA (cytosine-5)-methyltransferase 3-like
Description of TargetCatalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity).
Uniprot IDQ9UJW3
Protein Accession #NP_037501
Nucleotide Accession #NM_013369
  1. What is the species homology for "DNMT3L Antibody (OACA10713)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "DNMT3L Antibody (OACA10713)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "DNMT3L Antibody (OACA10713)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "DNMT3L Antibody (OACA10713)"?

    This target may also be called "cytosine-5-methyltransferase 3-like protein;DNA (cytosine-5)-methyltransferase 3-like;DNA (cytosine-5-)-methyltransferase 3-like;human cytosine-5-methyltransferase 3-like protein." in publications.

  5. What is the shipping cost for "DNMT3L Antibody (OACA10713)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "DNMT3L Antibody (OACA10713)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "DNMT3L Antibody (OACA10713)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "DNMT3L Antibody (OACA10713)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "DNMT3L"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DNMT3L"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DNMT3L"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DNMT3L"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DNMT3L"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DNMT3L"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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