DNMT3B Recombinant Protein (OPCD00858)

Catalog No: OPCD00858

DNMT3B Recombinant Protein (OPCD00858) using SDS-PAGE

DNMT3B Recombinant Protein (OPCD00858) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile581-Glu859
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Dnmt3b
• Gene Full Name: DNA methyltransferase 3B
• Alias Symbols: DNA (cytosine-5)-methyltransferase 3B;DNA methyltransferase MmuIIIB;DNA MTase MmuIIIB;MmuIIIB.
• NCBI Gene Id: 13436
• Protein Name: DNA (cytosine-5)-methyltransferase 3B
• Description of Target: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity).
• Uniprot ID: O88509
• Protein Accession #: NP_001003960.2
• Nucleotide Accession #: NM_001003960.4
• Protein Size (# AA): Ile581~Glu859
• Molecular Weight: 28kDa