DNMT3A Antibody - FITC Conjugated (OACA00372)

Catalog No: OACA00372

Size:100ug

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: FITC
• Application: WB
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Cloning, expression and chromosome locations of the human DNMT3 gene family.'Xie S., Wang Z., Okano M., Nogami M., Li Y., He W.-W., Okumura K., Li E.Gene 236:87-95(1999)
  [2] A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.'Chen T., Ueda Y., Xie S., Li E.J. Biol. Chem. 277:38746-38754(2002)
  [3] Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.'Kim G.-D., Ni J., Kelesoglu N., Roberts R.J., Pradhan S.EMBO J. 21:4183-4195(2002)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: DNMT3A
• Gene Full Name: DNA methyltransferase 3 alpha
• Alias Symbols: cysteine methyltransferase DNMT3A;DNA (cytosine-5-)-methyltransferase 3 alpha;DNA (cytosine-5)-methyltransferase 3A;DNA cytosine methyltransferase 3A2;DNA methyltransferase HsaIIIA;DNA MTase HsaIIIA;DNMT3A2;HESJAS;M.HsaIIIA;TBRS.
• NCBI Gene Id: 1788
• Protein Name: DNA (cytosine-5)-methyltransferase 3A
• Description of Target: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
• Uniprot ID: Q9Y6K1
• Protein Accession #: NP_072046.2; NP_715640.2; NP_783328.1; NP_783329.1; XP_005264232.1; XP_005264234.1
• Nucleotide Accession #: NM_022552.4; NM_153759.3; NM_175629.2; NM_175630.1; XM_005264175.3; XM_005264177.3