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Predicted Species Reactivity Human
Product Format Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
Clonality Polyclonal
Isotype IgG
Host Rabbit
Application IHC, IF
Additional Information Background: Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth .
:: Location: Nucleus
:: Positive Tissue: Liver cance, lung cancer
Reconstitution and Storage Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Immunogen KLH conjugated Synthetic peptide corresponding to Mouse Dnmt1
Purification Affinity purification
Datasheets/Manuals Printable datasheet for OASL00439
Application Info IHC, IF: 1:500 - 1:1000
Gene Symbol Dnmt1
Alias Symbols DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1
Protein Name DNA (cytosine-5)-methyltransferase 1
Swissprot Id P13864, P26358
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