DNASE1 Recombinant Protein (OPCD02770)

Catalog No: OPCD02770

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Subcellular Location: Nucleus, Secreted.
  Isoelectric Point: 4.6
  Residues: Gly19-Ala259
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 50 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: DNASE1
• Gene Full Name: deoxyribonuclease 1
• Alias Symbols: deoxyribonuclease I;deoxyribonuclease-1;DNase I, lysosomal;DNL1;Dornase alfa;DRNI;human urine deoxyribonuclease I.
• NCBI Gene Id: 1773
• Protein Name: Deoxyribonuclease-1
• Description of Target: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
• Uniprot ID: P24855
• Protein Accession #: NP_005214.2
• Nucleotide Accession #: NM_005223.3
• Protein Size (# AA): Gly19~Ala259
• Molecular Weight: 28kDa