DMPK Recombinant Protein (OPCD00606)

Catalog No: OPCD00606

DMPK Recombinant Protein (OPCD00606) using SDS-PAGE

DMPK Recombinant Protein (OPCD00606) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Ile201
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: DMPK
• Gene Full Name: DM1 protein kinase
• Alias Symbols: DM;DM protein kinase;DM1;DM1 protein kinase;DM1PK;DMK;DM-kinase;DMPK;dystrophia myotonica protein kinase;MDPK;MT-PK;myotonic dystrophy associated protein kinase;Myotonic dystrophy protein kinase;myotonin protein kinase A;myotonin-protein kinase;thymopoietin homolog.
• NCBI Gene Id: 1760
• Protein Name: Myotonin-protein kinase
• Description of Target: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
• Uniprot ID: Q09013
• Protein Accession #: NP_001075029.1
• Nucleotide Accession #: NM_001081560.2
• Protein Size (# AA): Met1~Ile201
• Molecular Weight: 27kDa