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DMPK Recombinant Protein (OPCD00606)

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Gene Symbol:
DMPK
Official Gene Full Name:
dystrophia myotonica protein kinase
Alias Symbols:
DM, DM1, DM1PK, DMK, DM-kinase, dystrophia myotonica 1 (includes dystrophia myotonia protein kinase), MDPK, MT-PK, Myotonic dystrophy protein kinase, Myotonin-protein kinase
NCBI Gene Id:
1760
Swissprot Id:
Q09013
Protein Accession #:
NP_001075029.1
Nucleotide Accession #:
NM_001081560.2
Protein Name:
Myotonin-protein kinase
Description of Target:
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Host:
E.coli
Conjugation:
Unconjugated
Molecular Weight:
27 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DMPK.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DMPK.
Product Format:
Lyophilized
Predicted Species Reactivity:
Human
Formulation:
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity:
> 95%
Source:
Prokaryotic Expressed Recombinant
Application:
SDS-PAGE, WB, ELISA, IP
Additional Information:
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
:::
Residues: Met1-Ile201
Tag:
N-terminal His Tag
Reconstitution and Storage:
Reconstitute in PBS or others.
Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals:
Printable datasheet for OPCD00606

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