DMPK Antibody (OAGA01529)

Catalog No: OAGA01529

Size:100 ul

DMPK antibody detects DMPK protein by western blot analysis.
A. 30 ug U87-MG whole cell lysate/extract
B. 30 ug SK-N-SH whole cell lysate/extract
C. 30 ug SK-N-AS whole cell lysate/extract
7.5 % SDS-PAGE
DMPK antibody (OAGA01529) dilution: 1:1000

DMPK antibody detects DMPK protein at membrane on mouse prostate by immunohistochemical analysis.
Sample: Paraffin-embedded mouse prostate.
DMPK antibody (OAGA01529) dilution: 1:500.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC-P, WB
• Reconstitution and Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Immunogen: Recombinant protein encompassing a sequence within the center region of human DMPK. The exact sequence is proprietary.
• Purification: Purified by antigen-affinity chromatography.
• Concentration: 1mg/ml
• Application Info: Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Target Info

• Gene Symbol: DMPK
• Gene Full Name: dystrophia myotonica-protein kinase
• Alias Symbols: DM, DM1, DMK, MDPK, DM1PK, MT-PK
• NCBI Gene Id: 1760
• Description of Target: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
• Uniprot ID: Q09013