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DMP1 Antibody - N-terminal region (OAAB14503)

400ul
$390.00
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Gene Symbol:
DMP1
NCBI Gene Id:
1758
Protein Name:
Dentin matrix acidic phosphoprotein 1
Swissprot Id:
Q13316
Protein Accession #:
NP_001073380.1
Alias Symbols:
DMP1, Dentin matrix acidic phosphoprotein 1
Replacement Item:
This antibody may replace item sc-54181 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
55782 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DMP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DMP1.
Immunogen:
This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB14503
Sample Type Confirmation:

DMP1 is supported by BioGPS gene expression data to be expressed in MDA-MB231

Isotype:
Ig
Application Info:
WB: 1:1000
Additional Information:
Precautions: DMP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite
:::
Cellular Location: Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calc
Tissue Location: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast
Publications:

Shin, J., Yang, J., Lee, J. C. & Baek, K.-H. Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence. Cell. Signal. 25, 2540-7 (2013). WB, Human 23993963

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