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DLG4 Antibody (OAAB21125)

200 ul
$390.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid
Clonality:
Polyclonal
Clone:
RB54010
Isotype:
Rabbit Ig
Host:
Rabbit
Application:
WB
Additional Information:
Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
DLG4
Official Gene Full Name:
discs large homolog 4
NCBI Gene Id:
1742
Swissprot Id:
P78352
Protein Accession #:
NP_001122299.1
Nucleotide Accession #:
NM_001128827.1
Alias Symbols:
PSD95, SAP90, SAP-90
Replacement Item:
This antibody may replace item sc-28941 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight:
80 kDa
Purification:
Protein A column purification, followed by peptide affinity purification
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DLG4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DLG4.
Immunogen:
This DLG4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 548-579 amino acids from human DLG4.
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Concentration:
500 ug/mL
Datasheets/Manuals:
Printable datasheet for anti-DLG4 (OAAB21125) antibody
Preservative:
0.09% Sodium Azide
Formulation:
Purified polyclonal antibody, supplied in PBS with 0.09% sodium azide.
Application Info:
WB: 1:2000
Target Reference:
Stathakis D.G.,et al.Genomics 44:71-82(1997).
Stathakis D.G.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Stathakis D.G.,et al.J. Neurochem. 73:2250-2265(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).

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