DKK3 Recombinant Protein (OPCD02749)

Catalog No: OPCD02749

DKK3 Recombinant Protein (OPCD02749) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Ctrl (+), SDS-PAGE, WB
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Isoelectric Point: 4.7
  Subcellular Location: Secreted
  Phenomenon Explanation: The possible reasons that the actual band size differs from the predicted are as follows:
  1. Splice Variants: Alternative splicing may create different sized proteins from the same gene.
  2. Relative charge: The composition of amino acids may affect the charge of the protein.
  3. Post-translational modification: Phosphorylation, glycosylation, methylation, etc.
  4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
  5. Polymerization of the target protein: Dimerization, multimerization, etc.
  Residues: Pro23-Ile349
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Dkk3
• Gene Full Name: dickkopf WNT signaling pathway inhibitor 3
• Alias Symbols: AW061014;C87148;dickkopf homolog 3;dickkopf-3;dickkopf-related protein 3;dkk-3;mDkk-3.
• NCBI Gene Id: 50781
• Protein Name: Dickkopf-related protein 3
• Description of Target: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
• Uniprot ID: Q9QUN9
• Protein Accession #: NP_056629.1
• Nucleotide Accession #: NM_015814.2
• Protein Size (# AA): Pro23~Ile349
• Molecular Weight: 47kDa