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Catalog No: OPPA01871 (Formerly GWB-95BD89)
Size:2UG
Price: $208.00
SKU
OPPA01871
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DKK1 Protein (OPPA01871)

Datasheets/ManualsPrintable datasheet for OPPA01871
Product Info
Predicted Species ReactivityHuman
Product FormatThe DKK1 protein solution contains PBS (pH 7.4) and 10% Glycerol. Physical appearance: Sterile filtered colorless solution.
HostHi-5 Baculovirus
::Product Introduction: DKK1 is part of the dickkopf family. DKK1 is a secreted protein with 2 cysteine rich regions and takes part in embryonic development through its inhibition of the WNT signaling pathway. High levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Induction of DKK1 contributes to the pathological cascade triggered by beta-amyloid and is significantly involved in the development of tau phosphorylation. DKK1 reduces the differentiation of osteoblastic precursor cells. DKK1 is an important member in multiple myeloma bone disease. DKK1 expression is reduced in human colon tumors, implying that DKK-1 plays a role as a tumor suppressor gene in this neoplasia; the Wnt/beta-catenin pathway is downregulated by the induction of DKK1 expression, a mechanism that is missing in colon cancer.
Product Description: DKK1 produced in Hi-5 is a single, glycosylated polypeptide chain containing 253 amino acids (32-266 a.a.) and having a molecular mass of 27.8 kDa.DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Reconstitution and StorageStore at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20CC for longer periods of time. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Avoid multiple freeze-thaw cycles.
PurityGreater than 85.0% as determined by SDS-PAGE.
Peptide SequenceADPTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRHSG RLVPRGSHHH HHH.
SourceSf9 Cells
Gene SymbolDKK1
Alias SymbolsSK, DKK-1
NCBI Gene Id22943
Protein NameDickkopf-related protein 1
Description of TargetProduct Description: Recombinant Human DKK1 produced in Hi-5 is a single, glycosylated polypeptide chain containing 253 amino acids (32-266 a.a.) and having a molecular mass of 27.8 kDa.DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Uniprot IDO94907
Protein Accession #NP_036374.1
Protein Size (# AA)Recombinant
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