DISP2 Antibody (OABF00522)

Catalog No: OABF00522

Size:100UL

Product Info

• Predicted Species Reactivity: Bovine|Dog|Horse|Human|Mouse|Porcine|Rat
• Product Format: Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Cell membrane
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human DISP2
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:300 - 1000
  IHC-P:1:200 - 400
  Fluorescent-IHC: 1:50 - 200
  Optimal dilutions should be determined by the end user.

Target Info

• Gene Symbol: DISP2
• Gene Full Name: dispatched RND transporter family member 2
• Alias Symbols: C15orf36;dispatched B;DISPB;HsT16908;LINC00594;long intergenic non-protein coding RNA 594;protein dispatched homolog 2.
• NCBI Gene Id: 85455
• Protein Name: Protein dispatched homolog 2
• Description of Target: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.
• Uniprot ID: A7MBM2