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- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for DIABLO Antibody (OAED00018) (OAED00018) |
|---|
| Predicted Species Reactivity | Human|Monkey |
|---|---|
| Clonality | Monoclonal |
| Clone | 79-1-83 |
| Isotype | IgG2b |
| Host | Mouse |
| Application | Western blot |
| Reconstitution and Storage | Long Term Storage : -20C |
| Immunogen | Recombinant full length human Smac/DIABLO. |
| Specificity | Recognizes human and monkey Smac/DIABLO. |
| Formulation | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Purity | Protein G affinity purified. |
| Application Info | Immunohistochemistry (paraffin sections) Western Blot (1μg/ml, ECL) Optimal conditions must be determined individually for each application. |
| Gene Symbol | DIABLO |
|---|---|
| Gene Full Name | diablo IAP-binding mitochondrial protein |
| Alias Symbols | DFNA64;diablo homolog, mitochondrial;diablo-like protein;direct IAP-binding protein with low pI;second mitochondria-derived activator of caspase;SMAC. |
| NCBI Gene Id | 56616 |
| Protein Name | Diablo homolog, mitochondrial |
| Description of Target | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. |
| Uniprot ID | Q9NR28 |
| Protein Accession # | NP_001265231.1; NP_001265232.1; NP_001265233.1; NP_001265271.1; NP_063940.1; NP_620308.1 |
| Nucleotide Accession # | NM_001278302.1; NM_001278303.1; NM_001278304.1; NM_001278342.1; NM_019887.5; NM_138930.3 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "DIABLO Antibody (OAED00018)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Monkey".
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How long will it take to receive "DIABLO Antibody (OAED00018)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".
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What buffer format is "DIABLO Antibody (OAED00018)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "DIABLO Antibody (OAED00018)"?
This target may also be called "DFNA64;diablo homolog, mitochondrial;diablo-like protein;direct IAP-binding protein with low pI;second mitochondria-derived activator of caspase;SMAC." in publications.
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What is the shipping cost for "DIABLO Antibody (OAED00018)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "DIABLO Antibody (OAED00018)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "DIABLO Antibody (OAED00018)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "DIABLO Antibody (OAED00018)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "DIABLO"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "DIABLO"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "DIABLO"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "DIABLO"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "DIABLO"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "DIABLO"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
