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DFFB Antibody - C-terminal region : FITC (ARP73821_P050-FITC)

100 ul
$289.00
In Stock
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Conjugation Options

ARP73821_P050 Unconjugated

ARP73821_P050-HRP Conjugated

ARP73821_P050-Biotin Conjugated

Gene Symbol:
DFFB
NCBI Gene Id:
1677
Swissprot Id:
O76075
Protein Accession #:
NP_004393
Alias Symbols:
DFFB, CAD, DFF2, DFF40,
Replacement Item:
This antibody may replace item sc-29871 from Santa Cruz Biotechnology.
Description of Target:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
Protein Size (# AA):
338
Molecular Weight:
37kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DFFB.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DFFB.
Immunogen:
The immunogen is a synthetic peptide directed towards the C-terminal region of Human DFFB
Predicted Species Reactivity:
Human
Peptide Sequence:
Synthetic peptide located within the following region: LRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHSINPYSN
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution and Storage:
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Concentration:
1 mg/ml
Protein Interactions:
DFFA; UBC; NUBP1; MARCKS; APP; CAND1; COPS5; CUL1; CUL2; CUL5; NEDD8; CIDEB; DFFB; TOP2A;
Blocking Peptide:
For anti-DFFB (ARP73821_P050-FITC) antibody is Catalog # AAP73821
Datasheets/Manuals:
Printable datasheet for anti-DFFB (ARP73821_P050-FITC) antibody
Conjugation:
FITC (FAM): Excitation 495 nm/ Emission 520 nm

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