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- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for DES Antibody (OAAF08296) |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | PBS, pH7.2, 0.03% Proclin 300, 50% glycerol |
| Clonality | Monoclonal |
| Clone | ABT-DES |
| Isotype | IgG |
| Host | Mouse |
| Application | Immunohistochemistry |
| Additional Information | Retrieval buffer: TRIS-EDTA of pH8.0 |
| :: | Description: Mouse monoclonal to Desmin |
| Reconstitution and Storage | -20°C |
| Immunogen | Synthetic peptide. |
| Purification | Immunogen affinity purified |
| Specificity | Anti-Desmin [ABT-DES] detects endogenous levels of total Desmin protein. |
| Application Info | IHC 1:200 - 1:400 |
| Gene Symbol | DES |
|---|---|
| Gene Full Name | desmin |
| Alias Symbols | cardiomyopathy, dilated 1F (autosomal dominant);CDCD3;CSM1;CSM2;desmin;epididymis secretory sperm binding protein;intermediate filament protein;LGMD1D;LGMD1E;LGMD2R. |
| NCBI Gene Id | 1674 |
| Protein Name | Desmin |
| Description of Target | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). |
| Uniprot ID | P17661 |
| Protein Accession # | NP_001918.3 |
| Nucleotide Accession # | NM_001927.3 |
| Molecular Weight | 53 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "DES Antibody (OAAF08296)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".
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How long will it take to receive "DES Antibody (OAAF08296)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "DES Antibody (OAAF08296)" provided in?
This item is provided in "PBS, pH7.2, 0.03% Proclin 300, 50% glycerol".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "DES Antibody (OAAF08296)"?
This target may also be called "cardiomyopathy, dilated 1F (autosomal dominant);CDCD3;CSM1;CSM2;desmin;epididymis secretory sperm binding protein;intermediate filament protein;LGMD1D;LGMD1E;LGMD2R." in publications.
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What is the shipping cost for "DES Antibody (OAAF08296)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "DES Antibody (OAAF08296)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "DES Antibody (OAAF08296)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "53 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "DES Antibody (OAAF08296)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "DES"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "DES"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "DES"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "DES"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "DES"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "DES"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
