DEK Antibody - N-terminal region : HRP (P100637_T100-HRP)

Catalog No: P100637_T100-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Rat, Cow, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DEK
• Predicted Homology Based on Immunogen Sequence: Cow: 78%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Rabbit: 85%; Rat: 85%
• Peptide Sequence: Synthetic peptide located within the following region: AAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-DEK (P100637_T100-HRP) antibody is Catalog # AAP30905 (Previous Catalog # AAPP01629)
• Reference: Orlic,M., et al., (2006) Genes Chromosomes Cancer 45 (1), 72-82
• Publications:

  Wang, N. et al. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS One 7, e39446 (2012). WB, Bovine, Guinea pig, Horse, Human, Pig, Rabbit, Rat 22761798

Target Info

• Gene Symbol: DEK
• Gene Full Name: DEK oncogene
• Alias Symbols: D6S231E
• NCBI Gene Id: 7913
• Protein Name: Protein DEK
• Description of Target: DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia
• Uniprot ID: P35659
• Protein Accession #: NP_003463
• Nucleotide Accession #: NM_003472
• Protein Size (# AA): 375
• Molecular Weight: 43kDa
• Protein Interactions: CUL3; SPOP; UBC; EED; IRF2BP2; GANAB; PTPN12; CSNK2A2; CSNK2A1; TP53BP1; ESR1; VTN; S100A9; RPL37A; DHX15; FTSJ3; WIBG; TMED9; EXOSC2; UTP14A; THRAP3; CAND1; COPS5; CDK2; YWHAZ; Cebpb; ELAVL1; SUMO1; SUMO2; RAD21; HDGF; KAT2B; EP300; CREBBP; HIST1H4A; HDA