DDX5 Antibody - C-terminal region : HRP (ARP36365_T100-HRP)

Catalog No: ARP36365_T100-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DDX5
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: SFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAY
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-DDX5 (ARP36365_T100-HRP) antibody is Catalog # AAP36365 (Previous Catalog # AAPP08424)
• Sample Type Confirmation:

  DDX5 is supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Guil,S., et al., (2003) Mol. Cell. Biol. 23 (8), 2927-2941
• Publications:

  Laux, A. et al. Localization of endogenous morphine-like compounds in the mouse spinal cord. J. Comp. Neurol. 520, 1547-61 (2012). WB, Mouse, Human, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig 22174317

Target Info

• Gene Symbol: DDX5
• Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box helicase 5
• Alias Symbols: p68, HLR1, G17P1, HUMP68
• NCBI Gene Id: 1655
• Protein Name: Probable ATP-dependent RNA helicase DDX5
• Description of Target: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX5 encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. DDX5 consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.
• Uniprot ID: P17844
• Protein Accession #: NP_004387
• Nucleotide Accession #: NM_004396
• Protein Size (# AA): 614
• Molecular Weight: 68kDa
• Protein Interactions: FUS; ESR1; DROSHA; MAPKAPK2; UBC; TP53; TUBGCP3; AURKB; SPRTN; AURKA; SUMO2; SUMO3; MDM2; CEP250; STAU1; RPA3; RPA2; RPA1; EED; EZH2; RNF2; SUZ12; rev; DDX17; PABPC4; PRPSAP1; PIN1; LRSAM1; FKBP10; ERO1L; DBNL; WDR4; PARK2; FBXO6; MAPK10; SP1; TARDBP; UBD