DDX39B Antibody (OACA02661)

Catalog No: OACA02661

Immunohistochemistry of paraffin-embeded human prostate at dilution of 1:100

All lanes: Spliceosome RNA helicase DDX39B antibody at 2ug/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15,000 dilution
Predicted band size: 49,51 kDa
Observed band size: 47 kDa

All lanes: Spliceosome RNA helicase DDX39B antibody at 2ug/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15,000 dilution
Predicted band size: 49,51 kDa
Observed band size: 47 kDa

Immunohistochemistry of paraffin-embeded human prostate at dilution of 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Spliceosome RNA helicase DDX39B protein (2-251AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: DDX39B
• Gene Full Name: DExD-box helicase 39B
• Alias Symbols: 56 kDa U2AF65-associated protein;ATP-dependent RNA helicase p47;BAT1;D6S81E;DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B;DEAD box protein UAP56;DEAD-box helicase 39B;HLA-B-associated transcript 1 protein;nuclear RNA helicase (DEAD family);spliceosome RNA helicase BAT1;spliceosome RNA helicase DDX39B;UAP56.
• NCBI Gene Id: 7919
• Protein Name: Spliceosome RNA helicase DDX39B
• Description of Target: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
• Uniprot ID: Q13838
• Protein Accession #: NP_004631
• Nucleotide Accession #: NM_004640