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DDX21 Antibody - N-terminal region (ARP36374_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP36374_P050-FITC Conjugated

ARP36374_P050-HRP Conjugated

ARP36374_P050-Biotin Conjugated

Gene Symbol:
DDX21
Official Gene Full Name:
DEAD (Asp-Glu-Ala-Asp) box helicase 21
NCBI Gene Id:
9188
Protein Name:
Nucleolar RNA helicase 2
Swissprot Id:
Q9NR30
Protein Accession #:
NP_004719
Nucleotide Accession #:
NM_004728
Alias Symbols:
GUA, GURDB, RH-II/GU, RH-II/GuA
Replacement Item:
This antibody may replace item sc-104860 from Santa Cruz Biotechnology.
Description of Target:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
Protein Size (# AA):
783
Molecular Weight:
86kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DDX21.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DDX21.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human DDX21
Predicted Species Reactivity:
Horse, Human, Rat, Yeast
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Horse: 79%; Human: 100%; Rat: 91%; Yeast: 83%
Complete computational species homology data:
Anti-DDX21 (ARP36374_P050)
Peptide Sequence:
Synthetic peptide located within the following region: MPGKLRSDAGLESDTAMKKGETLRKQTEEKEKKEKPKSDKTEEIAEEEET
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
HUWE1; PA2G4; KPNA3; CEP250; SUMO2; SUMO3; STAU1; IVNS1ABP; UBC; MDM2; LGR4; SUMO1; ERG; WWOX; EED; rev; SRPK2; SRPK3; FBXO6; TARDBP; LYN; AICDA; PAN2; vif; WHSC1; VCAM1; ITGA4; IL7R; FN1; CSNK2A1; YWHAE; SMURF1; H2AFX; APTX; ESR1; FTSJ3; PCDHA2; RRP7A; R
Blocking Peptide:
For anti-DDX21 (ARP36374_P050) antibody is Catalog # AAP36374 (Previous Catalog # AAPP08432)
Datasheets/Manuals:
Printable datasheet for anti-DDX21 (ARP36374_P050) antibody
Sample Type Confirmation:

DDX21 is supported by BioGPS gene expression data to be expressed in HepG2

Target Reference:
Yang,H., et al., (2005) FEBS J. 272 (15), 3788-3802
Publications:

De Wever, V. et al. Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21. PLoS One 7, e39510 (2012). WB, Horse, Human, Rat, Yeast 22761809

Laux, A. et al. Localization of endogenous morphine-like compounds in the mouse spinal cord. J. Comp. Neurol. 520, 1547-61 (2012). WB, Horse, Human, Rat, Yeast 22174317

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