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DDX21 Antibody - C-terminal region (ARP36375_T100)

100 ul
$229.00
In Stock
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Conjugation Options

ARP36375_T100-FITC Conjugated

ARP36375_T100-HRP Conjugated

ARP36375_T100-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Pig, Rabbit, Rat
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
DDX21
Official Gene Full Name:
DEAD (Asp-Glu-Ala-Asp) box helicase 21
NCBI Gene Id:
9188
Protein Name:
Nucleolar RNA helicase 2
Swissprot Id:
Q9NR30
Protein Accession #:
NP_004719
Nucleotide Accession #:
NM_004728
Alias Symbols:
GUA, GURDB, RH-II/GU, RH-II/GuA
Replacement Item:
This antibody may replace item sc-104860 from Santa Cruz Biotechnology.
Description of Target:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX21 encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
Protein Size (# AA):
783
Molecular Weight:
86kDa
Purification:
Protein A purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DDX21.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DDX21.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human DDX21
Predicted Homology Based on Immunogen Sequence:
Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 93%; Rat: 93%
Complete computational species homology data:
Anti-DDX21 (ARP36375_T100)
Peptide Sequence:
Synthetic peptide located within the following region: FRGQRDGNRRFRGQREGSRGPRGQRSGGGNKSNRSQNKGQKRSFSKAFGQ
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
HUWE1; PA2G4; KPNA3; CEP250; SUMO2; SUMO3; STAU1; IVNS1ABP; UBC; MDM2; LGR4; SUMO1; ERG; WWOX; EED; rev; SRPK2; SRPK3; FBXO6; TARDBP; LYN; AICDA; PAN2; vif; WHSC1; VCAM1; ITGA4; IL7R; FN1; CSNK2A1; YWHAE; SMURF1; H2AFX; APTX; ESR1; FTSJ3; PCDHA2; RRP7A; R
Blocking Peptide:
For anti-DDX21 (ARP36375_T100) antibody is Catalog # AAP36375 (Previous Catalog # AAPP08433)
Datasheets/Manuals:
Printable datasheet for anti-DDX21 (ARP36375_T100) antibody
Sample Type Confirmation:

DDX21 is supported by BioGPS gene expression data to be expressed in HepG2

Target Reference:
Henning,D., et al., (2003) J. Biol. Chem. 278 (52), 52307-52314
Publications:

Miyazawa, N. et al. Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA. Genes Cells 19, 273-86 (2014). WB, Cow, Dog, Guinea Pig, Horse, Human, Pig, Rabbit, Rat 24495227

Romanova, L. et al. Critical role of nucleostemin in pre-rRNA processing. J. Biol. Chem. 284, 4968-77 (2009). WB, Cow, Dog, Guinea Pig, Horse, Human, Pig, Rabbit, Rat 19106111

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