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Catalog No: OPCD02695
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OPCD02695
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Datasheets/ManualsPrintable datasheet for DDR2 Recombinant Protein (OPCD02695)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: His578-Pro817
::Subcellular Location: Cell membrane; Single-pass type I membrane protei
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolDDR2
Gene Full Namediscoidin domain receptor tyrosine kinase 2
Alias SymbolsCD167 antigen-like family member B;cell migration-inducing protein 20;discoidin domain receptor 2;discoidin domain receptor family, member 2;discoidin domain-containing receptor 2;discoidin domain-containing receptor tyrosine kinase 2;hydroxyaryl-protein kinase;MIG20a;migration-inducing gene 16 protein;neurotrophic tyrosine kinase receptor related 3;Neurotrophic tyrosine kinase, receptor-related 3;NTRKR3;receptor protein-tyrosine kinase TKT;TKT;TYRO10;tyrosine-protein kinase TYRO10;WRCN.
NCBI Gene Id4921
Protein NameDiscoidin domain-containing receptor 2
Description of TargetTyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Uniprot IDQ16832
Protein Accession #NP_001014796.1
Nucleotide Accession #NM_001014796.1
Protein Size (# AA)His578~Pro817
Molecular Weight33kDa
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