DDR2 Antibody (OAEC04353)

Catalog No: OAEC04353

Size:100 ug/100 ul

Western blot analysis using DDR2 mouse mAb against truncated DDR2 recombinant protein.

Immunohistochemical analysis of paraffin-embedded human skeletal musle tissues using DDR2 mouse mAb.

Confocal immunofluorescence analysis of A549 cells using DDR2 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Ascitic fluid containing 0.03% sodium azide
• Clonality: Monoclonal
• Clone: 3B11E4
• Isotype: IgG1
• Host: Mouse
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of human DDR2 expres sed in EColi.
• Concentration: 1 mg/ml
• Application Info: WB: 1/500 - 1/2000
  IHC: 1/200 - 1/1000
  IF: 1/200 - 1/1000
  ELISA: 1/10000
  

Target Info

• Gene Symbol: DDR2
• Gene Full Name: discoidin domain receptor tyrosine kinase 2
• Alias Symbols: TKT, WRCN, MIG20a, NTRKR3, TYRO10
• NCBI Gene Id: 4921
• Description of Target: DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes . The fam ily has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions.This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the5' UTR results in multiple transcript variants encoding the same protein.
• Uniprot ID: Q16832