DDR1 Antibody (OAAD00267)

Catalog No: OAAD00267

Size:0.1ml

western blot analysis using DDR1 mouse mAb against truncated MBP-DDR1 recombinant protein (1).

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: 2G4E12
• Isotype: IgG1
• Host: Mouse
• Application: WB
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli.
• Formulation: Ascitic fluid containing 0.03% sodium azide.
• Application Info: Western Bloting: 1/500 - 1/2000.
  ELISA: Propose dilution 1/10000.
  Not yet tested in other applications.
  Determining optimal working dilutions by titration test.
• Reference: 1. FASEB J. 2000 May;14(7):973-81.
  2. Exp Eye Res. 2001 Jan;72(1):87-92.
  3. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.

Target Info

• Alias Symbols: CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, CD167, EDDR1, MCK10, NTRK4, PTK3A
• NCBI Gene Id: 780
• Description of Target: DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
• Uniprot ID: Q08345