DCX Antibody - C-terminal region (ARP41332_P050)

Catalog No: ARP41332_P050

WB Suggested Anti-DCX Antibody Titration: 0.2-1 ug/ml
Positive Control: 293T cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Dog, Horse, Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DCX
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%
• Peptide Sequence: Synthetic peptide located within the following region: TAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPIS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-DCX (ARP41332_P050) antibody is Catalog # AAP41332 (Previous Catalog # AAPP22687)
• Reference: Zhang,Y., (2007) Biochem. Biophys. Res. Commun. 363 (3), 694-700

Target Info

• Gene Symbol: DCX
• Gene Full Name: Doublecortin
• Alias Symbols: DC, DBCN, LISX, SCLH, XLIS
• NCBI Gene Id: 1641
• Protein Name: Neuronal migration protein doublecortin
• Description of Target: In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The protein contains two doublecortin domains, which bind microtubules. In addition, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.
• Uniprot ID: O43602
• Protein Accession #: NP_000546
• Nucleotide Accession #: NM_000555
• Protein Size (# AA): 441
• Molecular Weight: 49kDa
• Protein Interactions: KIFC3; GOLGA2; TRIM23; KRTAP10-8; KRT40; RINT1; MID2; SPAG5; IKZF1; CALCOCO2; ZBTB5; TRIM27; MEOX1; FBXO25; APP; PPP1R9B; PPP1CA; PAFAH1B1; ACD; TINF2; POT1; TERF1; SPP1; USP9X; NFASC; TRIM39; AP1M1; AP2M1; DCX; CDK5;